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Properties of substance:

6-aminohexanoic acid

Synonyms:

amicar
epsilon-aminocaproic acid

Group of substances:

organic

Physical appearance:

colorless leaflets crystals

Empirical formula (Hill's system for organic substances):

C6H13NO2

Structural formula as text:

H2N(CH2)5COOH

Molar/atomic mass: 131.1729

Melting point (°C):

202-203

CAS №: 60-32-2

Solubility (g/100 g of solvent):

chloroform: practically insoluble [Ref.]
diethyl ether: practically insoluble [Ref.]
ethanol: slightly soluble [Ref.]
methanol: sparingly soluble [Ref.]
water: 50.48 (25°C) [Ref.]

Dissociation:

pI (1) = 7.6 (25°C, water)
pKBH+ (1) = 10.8 (25°C, water)
pKa (1) = 4.37 (25°C, water)

Standard molar enthalpy (heat) of formation ΔfH (298 K, kJ/mol)

-637.3 (s) [Ref.]

LD50 (mg/kg):

3300 (rats, intravenous)
14300 (mice, oral)
4900 (mice, intravenous)
= 1258
= 1319
= 1098
= 1613
= 1538
= 1203

References:

  1. CRC Handbook of Chemistry and Physics. - 95ed. - CRC Press, 2014. - pp. 3-20
  2. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 341
  3. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 91
  4. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 11ed. - Wiley-interscience, 2004. - pp. 161-162
  5. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 455
  6. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 319
  7. Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 457-458 [Russian]
  8. Свойства органических соединений: Справочник. - Под ред. Потехина А.А. - Л.: Химия, 1984. - pp. 186-187 [Russian]
  9. Хёрд Ч.Д. Пиролиз соединений углерода. - Л.-М.: ГОНТИ РКТП СССР, 1938. - pp. 463 [Russian]
  10. Химическая энциклопедия. - Т. 1. - М.: Советская энциклопедия, 1988. - pp. 136 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru