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Properties of substance:

amitriptyline hydrochloride



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C20H24ClN

Molar/atomic mass: 313.864

Melting point (°C):

195-199

CAS №: 549-18-8

Solubility (g/100 g of solvent):

chloroform: very soluble [Ref.]
ethanol: very soluble [Ref.]
water: very soluble [Ref.]

Dissociation:

pKa (1) = 9.4 (25°C, water)

LD50 (mg/kg):

280 (mice, oral)
26 (mice, intravenous)

References:

  1. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 346
  2. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 96-97
  3. Milne G.W.A. Gardner's Commercially Important Chemicals. - Wiley-Interscience, 2005. - pp. 30-31
  4. The Merck Index 11th ed., Merck & Company, 1989. - pp. 80
  5. Регистр лекарственных средств России: Энциклопедия лекарств. - 11 изд. - М.: ООО РЛС-2004, 2004. - pp. 81 [Russian]
  6. Химическая энциклопедия. - Т. 1. - М.: Советская энциклопедия, 1988. - pp. 149 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru